Francesca De Sapio is an Italian actress and acting coach.
The daughter of an architect, she was born in Rome. After her fathers work took him to the United States, she started studying acting in Texas.
In the early 1980s she became a tutor at the Actor's Studio, where she also studied under Lee Strasberg. In 1985 she co-founded with Joseph Perruccio the Duse Studio in New York, an international centre for training in acting, film production and theater. In 1987, Duse moved to Montecatini, Italy, and then to its current base in Rome.